1546 EITHER CAT 25 THE EFFECTS OF ANTIHYPERTENSIVE DRUGS

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THE EFFECTS OF ANTI-HYPERTENSIVE DRUGS ON DIASTOLIC AND SYSTOLIC HYPERTENSION IN CHINESE

1546, Either, cat: 25

THE EFFECTS OF ANTI-HYPERTENSIVE DRUGS ON DIASTOLIC AND SYSTOLIC HYPERTENSION IN CHINESE

Y.F. Han, X.H. Fan, K. Sun, W.J. Li, X.J. Wang, J.Z. Cheng, Y.S. Zhen, Y. Zheng,

X. Yang, R.T. Hui

FuWai hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China


Objective: To investigate the different efficacy of antihypertensive drugs in patients with isolated systolic hypertension(ISH), isolated diastolic hypertension(IDH), and combined systolic and diastolic hypertension(SDH).

Backgrounds: Few studies compared the relative efficacy of antihypertensive drug classes for diastolic and systolic hypertension. Design and methods: We recruited 442 ISH,

104 IDH and 1352 SDH patients from HeNan province, China. They were randomly divided into four groups receiving Hydrochlorothiazide, Atenolol, Nifedipine or Captopril respectively.

Results: After adjustment for traditional risk factors: In ISH patients, the reduction in systolic blood pressure(SBP) was lower in Atenolol group than that in Hydrochlorothiazide (P=0.033) and Nifedipine (P=0.005) groups; Nifedipine decreased diastolic blood pressure(DBP) to a greater extent than Hydrochlorothiazide (P=0.015); The reduction in pulse pressure(PP) was greater in Hydrochlorothiazide than that in Atenolol (P=0.006) and Captopril(P=0.019) groups. In IDH patients, the reduction in SBP was greater in Hydrochlorothiazide group than that in Atenolol (P=0.040) and Captopril (P=0.016) groups; Hydrochlorothiazide decreased PP to a greater extent than Atenolol (P=0.029) and Captopril (P=0.031).In SDH patients, the reduction in SBP was greater in Nifedipine group than that in other groups (P<0.001); Nifedipine decreased DBP to a greater extent than Hydrochlorothiazide and Atenolol(P<0.001). The reduction in PP was significantly greater in Hydrochlorothiazide and Nifedipine groups than that in Atenolol and Captopril groups (P<0.001).

Conclusions: In reducing blood pressure, TZDs seems to be the most effective antihypertensive drug for ISH; B-blocks and ACEI seem to be more effective for IDH; TZDs and CCBs seem to be more effective for SDH.



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1546 EITHER CAT 25 THE EFFECTS OF ANTIHYPERTENSIVE DRUGS


Tags: antihypertensive drugs, effective antihypertensive, antihypertensive, effects, either, drugs