CURRICULUM VITAE CAIROUNIVERSITY FACULTY OF PHARMACY NAME NESRINE S

CURRICULUM VITAE BLANCA GARCÍA
5 RESUMEN DE CURRICULUM VITAE 1 DATOS
9 CURRICULUM VITAE I PERSONAL HOWARD A

CURRICULUM VITAE DR ABDELGHAFFAR M ELDEMERDASH
CURRICULUM VITAE JOSÉ JUAN BONOME BÁRCENA
CURRICULUM VITAE DR CONSTANTINO MORERA PEREZ PROFESOR

Curriculum Vitae

CairoUniversity

CURRICULUM VITAE CAIROUNIVERSITY FACULTY OF PHARMACY NAME NESRINE S

Faculty of Pharmacy

Name:

Nesrine S. El Sayed

Title:

Associate professor of pharmacology and toxicology

Department:

Pharmacology and toxicology

E-mail:

[email protected]

Website:

[email protected]

Mobile:

01001472952

Phone:

+202 23080322


CURRICULUM VITAE CAIROUNIVERSITY FACULTY OF PHARMACY NAME NESRINE S











Education

  • Academic Degrees

  • 5/2012-till present Associate professor of pharmacology & Toxicology-German University in Cairo

  • 10/2007- 4/2012 Lecturer of pharmacology & Toxicology- German university in Cairo

  • 4/2004 – 9/2007: Lecturer of Pharmacology & Toxicology- Cairo university



  • 9/1998–4/2004: Assistant lecturer of Pharmacology &Toxicology

Department of pharmacology & Toxicology, Cairo University

  • 12/1993 – 9/1998: Instructor of Pharmacology & Toxicology

Department of Pharmacology and Toxicology, Cairo University


  • Research interest

Head of the neurodegenerative research group in the German university in Cairo.

Development of the neurobehavioural lab in the university and the head of the neurodegenerative research group

Supervising master and PhD thesis in Cairo university, German university in Cairo and Bani sweif university

Supervision on master and doctoral thesis

  • Evaluation of antidepressant-like activity of drugs from natural source



  • Neuroprotective agents from natural source in a model of Parkinson disease: Approaches to preventing degenerative diseases.

  • Possible protective effects of certain antioxidants against carmustine-induced hepatotoxicity.

  • Pharmacological Study of the Possible Protective Effects of Some Antioxidants against Experimentally-Induced Hepatotoxicity in Rats.(PhD)

  • Possible effectiveness of certain natural products in modulating hypersensitivity in experimental animals (Master).


  • Pharmacological study of the possible antidepressant activity of some Lamiaceae plants extracts in experimental animals.


  • Study of the possible neuroprotective effects of certain natural products in experimentally-induced dementia in rats.


  • Anti-allergic mechanism of Thymoquinone on airway induced hypersensitivity in experimental animals.


  • Hepatoprotective effect of Grape seed extract on Ccl4-induced liver injury.


  • The protective effect of curcumin on isolated rat hepatocytes against Ccl4 toxicity compared with silymarin


In the GUC

Main supervisor:Master thesis

  1. Role of Grape seed extract in Lipopolysaccharide- induced Alzheimer’s disease model: Possible implicationson Amyloid Beta Formation.



  1. Role of Thymoquinone in Alzheimer’s diseaseTargeting cholinergic System.

  2. Possible role of the combination therapy of celecoxib and 3-acetyl-11-keto-β-boswellic acid in treatment of Lipopolysaccharide-induced Alzheimer’s disease in mice

  3. Role of hesperidin as a novel anti-inflammatory and antioxidant bioflavonoid in attenuating LPS- induced cognitive deficits in mice.

  4. Possible role of resveratrol and pluripotent stem cell targeting both estradiol and neprilysin pathways in LPS induced Alzheimer model.

  5. The Role of Pan Peroxisome Proliferator Activated Receptor Activator Agonist Bezafibrate in Attenuating the Alzheimer’s Neurodegeneration Induced by Intracerebroventricular Streptozotocin.

  6. “The role of valproic acid, a histone deacetylase inhibitor, in the management of the downstream effects of central insulin signaling transduction pathway in intracerebroventricular streptozotocin Alzheimer’s disease mouse model”

  7. Role of pioglitazone and Simvastatin in LPS- induced Alzheimer disease.

  8. Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer’s Drug Leads

  9. Formulation and characterization of Novel Betamethasone- loaded Nanoparticles (Liposomes, Niosomes and Transferosomes) for Selective Targeting of Immune and Inflammatory Diseases and Testing Them on Rheumatoid Arthritis Animal Models.

  10. Evaluation of Plant Phenolic Metabolites as a potential therapy for Neurodegenerative diseases.

  11. Role of thymoquinone against glutamate induced neurotoxicity in male albino rats. Supervision of PhDs:

  1. Neuroprotective effect of Thymoquinone against lipopolysaccharide induced Alzheimer in an animal model.

  2. Evaluation of the antidepressant activity of certain natural drugs. Ph D thesis.

  3. Possible effect of nitric oxide pathway in LPS-induced model of Alzheimer’s disease.

  4. Possible role of 3-acetyl-11-keto-beta boswellic acid on regulation of neurobehavioral dysfunction and expression of nuclear factor kappa B and amyloid precursor protein in LPS model of Alzheimer’s disease”.

  5. Effect of combination therapy of caffeinated coffee and selective 5-HT4 agonist, Prucalopride, in an Alzheimer's Disease mouse model: possible implications on Amyloid Beta formation. By Nouran Al Shehaby. International PhD student



  1. Neuroprotective effect of curcumin against streptozotocin induced injury in an animal model of alzheimer.

  2. Modulation of the cognitive impairment associated with Alzheimer’s disease by histone deacetylase inhibitors: possible involvement of Glycogen synthase kinase 3 enzyme.

  3. Attenuation of the cognitive impairment associated with Alzheimer’s disease by Fibrates: possible involvement of the inflammatory pathway. Nourmina Baher Ragheb, TA in pharmacology & Toxicology department, GUC, March 2015



Teaching

Course Title

Undergraduate Courses

(General Program)

Faculty of pharmacy - Cairo university

  1. Participation in teaching & supervising the practical courses of pharmacology, toxicology and bioassay (1994-2004)

  2. Participation in teaching the course of Toxicology in Cairo University in the first semester of the academic years: 2004-2005, 2005-2006, 2006-2007

  3. Participation in teaching the course of Pharmacology in Cairo University in the second semester of the academic years: 2005-2006, 2006-2007

  4. Participation in teaching the course of Toxicology in Beni Sweif University in the first semester of the academic years: 2005-2006

  5. Participation in teaching the course of Pharmacology in Beni Sweif University in the first and second semesters of the academic years: 2006-2007

  6. Participation in teaching the First aid course in Beni Sweif University in the first semester of the academic years: 2006-2007

Faculty of pharmacy & Biotechnology-German university in Cairo

  1. Teaching the First aid course to the fifth year students of the academic years: 2007 till now

  2. Teaching the Clinical pharmacy I&II courses to the fifth year students of the academic years: 2007 till now

  3. Teaching the pharmacotherapeutics course to the fifth year students of the academic years: 2007 till now

  4. Participation in teaching the pharmacology I & II courses to the fifth year students of the academic years: 2007 till now

Undergraduate Courses (Clinical Program)

----------------------------------

Postgraduate Courses

Teaching the following courses to the post graduate students:

    1. Advanced pharmacology and immunopharmacology (Diploma)

    2. Toxicometrics (Master Degree)

























Career History and Professional Experience

Titles

Associate professor of pharmacology and toxicology

Awards

Reviewer for several international journals e.g. BJMMR, BFOPCU

Member in the European behavioural pharmacology society (ebps)

Contributing in writing a book entitled ‘’ Tea in health and disease prevention’’ 2013, Elsevier

Awards of international publishing from Cairo university

Projects

Applied to a project in STDF

Publications and Presentations

Contributing a Chapter in an edited book:

The Protective Effect of Green Tea Against Experimentally-Induced Lung Fibrosis in Rats. In Victor R Preedy., editor. Tea in Health and Disease Prevention, El Sevier 2013, p. 281–304, DOI: 10.1016/B978-0-12-384937-3.00054-9


  1. Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease. Adv Exp Med Biol. 2015; 822:107-18.

Nesrine S. El-Sayed and Yasmeen Bayan (2015)

  1. Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer’s Drug Leads. Bio Med Research International, Volume 2014, Article ID 843263, 10 pages. Yara Hassaan, Heba Handoussa, Ahmed H. El-Khatib, MichaelW. Linscheid, Nesrine El Sayed, and Nahla Ayoub



  1. Interplay between LPS induced oxidative stress and Amyloid beta deposition in Alzheimer’s disease and treatment with Glycyrrhizin; Journal of Experimental and Applied Animal Sciences; volume 1, issue 2, pp. 212-228, 2014. Authors: Ragwa Mansour, Nadia Sharaf, Nesrine S. El Sayed, Laila G. Mahran





  1. Protective Effect of Aframomum melegueta phenolics Against CCl4-Induced Rat Hepatocytes Damage; Role of Apoptosis and Pro-inflammatory Cytokines inhibition. Ali M. El-Halawany, Riham Salah El Dine, Nesrine S. El Sayed and Masao Hattori. Sci.Rep. 4, 5880; DOI:10.1038/srep05880 (2014).IF: 5.079



  1. Overexpression of NMDAR2B in an inflammatory model of Alzheimer’s disease: Modulation by NOS inhibitors” Ahmed Maher, M.Sc; Nesrine S El-Sayed, Ph.D; Hans G Breitinger, Ph.D; Mohamed Zakaria Gad, Ph.D Brain Research Bulletin 109 (2014) 109–116



  1. “TEMPOL, a Membrane-Permeable Radical Scavenger, Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice: a Key Role for Superoxide Anion.” Eur.J.Pharmacol., 663(1-3):68-73, 2011.

  2. Phytochemical and biological investigation of the extracts of Nigella sativa L. seed waste. Drug Test. Analysis , 3, 245-254, 2011

  3. “Bioactive aqueous extract of Nigella sativa L. seed waste: Formulation and evaluation”. Journal of Chemical and Pharmaceutical Research, 3(2):213-225, 2011

  4. The Protective Effect of Quercetin, Green Tea or Malt Extracts against Experimentally-Induced Lung Fibrosis in Rats”. African Journal of Pharmacy and Pharmacology, 3(5):191-201, 2009.

  5. “Protective Outcome of some Natural Extracts in Ccl4-induced Hepatotoxicity in vitro; Modulatory Role of Inducible NOS inhibitors versus Non- Selective ones.” 16th Zagazig Annual Medical Conference, 22-25 March, special issue: 230-262, 2009.

  6. Promising Therapy for Alzheimer’s disease Targeting The Angiotensin-Converting Enzyme And The Cyclooxygense 2 isoform.” Drug Discov.Ther.2009;3(6):307-315.

  7. Neuroprotective Effects of Deprenyl and Certain Natural Products against Paraquat – Induced Behavioral and Neurochemical Changes in Rats”. Journal of the Egyptian Society of Toxicology, 39: 1-12, 2008.

  8. “Ischemia-Reperfusion Liver Injury in Rats; Can Herbal Medicines Really Protect?” Mansoura Journal of Pharmaceutical Sciences, 24(2):198-212, 2008.

  9. “Attenuation of Neurotoxicity Induced by Sub-Chronic Paraquat Administration in Rats by Deprenyl, Quercetin, Green tea and Malt Extract”. The New Egyptian Journal of Medicine, 37(5) (suppl.), 90-103, 2007.

  10. “The Modulating Effect of Hesperidin Treatment on the Oxidative Stress and Polyol Pathway in Kidney of STZ-Induced Diabetic Rats”. The New Egyptian Journal of Medicine, 35(6) (suppl.), 76-85, 2006

CONFERENCE PARTICIPATION & ATTENDENCE:

  1. Oral presentation entitled: Role of the Combination Therapy of Pioglitazone and Simvastatin in Lipopolysaccharide Induced Alzheimer Disease Model in Mice in the conference: 2nd world congress on neurotherapeutics (DDDN): Dilemmas, Debates , Discussions, Prague, Czech republic, from 3-6 September, 2015



  1. Accepted abstract entitled: Evidence of novel mechansim of acetyl-11-keto-beta-boswellic acid (AKBA): possible neuroprotective approch aganist lps induced cognitive impairment in mice, in the 2015 Alzheimer's Disease Congress, London, united kingdom, from 23rd-25 June, 2015



  1. Abstract as poster presentation entitled: Glycyrrhizin attenuates oxidative stress and neuroinflammation: novel approach targeting alzheimer's disease in the 12th International Conference on Alzheimer's and Parkinson's Diseases, AD/PD™ 2015, Nice, France, from 18-22 March, 2015



  1. Abstract as poster presentation entitled: Neuroprotective effect of thymoquinone against lipopolysaccharide-induced behavioral and neurotransmitter alteration in an animal model in the 12th International Conference on Alzheimer's and Parkinson's Diseases, AD/PD™ 2015, Nice, France, from 18-22 March, 2015



  1. Abstract as poster presentation entitled: Role of hesperidin as a novel anti-inflammatory and antioxidant bioflavonoid in attenuating LPS- induced cognitive deficits in mice in the 12th International Conference on Alzheimer's and Parkinson's Diseases, AD/PD™ 2015, Nice, France, from 18-22 March, 2015



  1. Abstract as poster presentation entitled: NMDAR2B is overexpressed in Neurodegeneration: Modulation by NOS inhibitors in the the Lancet Neurology Autoimmune Disorders Conference: NMDA receptors and other novel targets of autoimmune neurological disease: from symptoms to synapses, Barcelona, Spain from 26-27 March, 2015



  1. oral presentation in 10th International Congress of the European Union Geriatric Medicine Society, entitled: Role of Glycyrrhizin in the modulation of neurotransmitters and memory alteration in Alzheimer’s disease, which was held in De Doelen, Rotterdam, The Netherlands, 17-19 September 2014



  1. Abstract as a poster presentation at 10th International Congress of the European Union Geriatric Medicine Society, 17-19 September 2014, De Doelen, Rotterdam, The Netherlands, entitled: Neuroprotective effect of thymoquinone against lipopolysaccharide induced alzheimer in an animal model



  1. Oral presentation in the 1st world congress in geriatrics and neurodegenerative diseases which was held in Corfu-Greece in 10-13 April, 2014, entitled:Possible role of Resveratrol targeting Estradiol and Neprilysin pathways in lipopolysaccharide model of alzheimer disease



  1. Abstract accepted as a poster presentation XXI World Congress of Neurology which will be held in Vienna-Austria, 21-26September, 2013. Title: "Thymoquinone improves cognitive function and increases a-7nAChRs expression in a rat model of neuroinflammation"



  1. Abstract accepted as a poster presentation in 9th International Congress on Autoimmunity, Nice, March 26-30, 2014. Possible role of the combination therapy of celecoxib and 3-acetyl-11-keto-beta-boswellic acid in treatment of lipopolysaccharide-induced alzheimer's disease in mice.



  1. Abstract presented as an E-Poster Presentation entitled: role of grape seed extract in lipopolysaccharide induced alzheimer’s disease model: possible implication on amyloid beta formation, during the XX World Congress on Parkinson’s Disease and Related Disorders held on 8 -11 December 2013 in Geneva, Switzerland.



  1. Oral presentation entitled: “The Role of Systemic Inflammation, Nitric Oxide Signaling, and NMDA Receptors in an Experimental Model of Alzheimer’s Disease. 11th National Conference of Biochemistry and Molecular Biology & Their Role inDevelopment and Environment" that was held in Ain Shams University 30 Mar-1 Apr 2014



  1. Oral presentation in 2nd Biotechnology world congress held in Dubai 18-21-2013 February, UAE. “Promising Therapy for Alzheimer’s disease Targeting The Angiotensin-Converting Enzyme And The Cyclooxygense 2 isoform.”



  1. Abstract accepted in ISSX 2010 meeting, taking place in Istanbul, Turkey from 4-8 September 2010. Attenuation of Neurotoxicity Induced by Sub-Chronic Paraquat Administration in Rats by Deprenyl, Quercetin, Green tea and Malt Extract”.



  1. Abstract accepted in IUTOX 2010, taking place in Barcelona, Spain from 19-23 July 2010Abstract: Natural extracts facing hepatocyte injury in vitro: Does inducible nitric oxide inhibition differ from that of non-selective nitric oxide inhibition concerning modulation of the protective outcome



  1. Abstract accepted in EACPT 2009, taking place in Edinburgh, Scotland from 12-15 July 2009. Abstract: “Potential in vitro antioxidant and protective effects of sylimarin on carmustine-induced damage in HepG2 cells”.



  1. Abstract. Accepted during “Al-Azhar 5th International Conference for Pharmaceutical and Biological Sciences” held in Air Defense House-Cairo, 2008. Abstract: “Gallic acid protects HepG2 cells from carmustine cytotoxicity”



  1. The protective Effect of Quercetin, Green Tea, Malt Extract and Deprenyl on Experimentally-Induced Pulmonary Fibrosis in Rats”. (Abstract). Accepted in the “31st conference of pharmaceutical Sciences” ” held in Air Defense House-Cairo, 2008.



  1. “Protective Effect of the Seed Waste extracts of Nigella Sativa L. on Acute Ccl4-induced Liver Injury”. (Abstract). Accepted during the “31st conference of pharmaceutical Sciences” ” held in Air Defense House-Cairo, 2008.



  1. Abstract accepted in 30th Conference of Pharmaceutical Sciences, December 19-21, 2006. Abstract: Effect of the aqueous extract of Marjoram and Nigella sativa oil on histamine released by compound 48/80 from rat peritoneal mast cells.



  1. Abstract accepted in 24th International Conference on Science and Technology, October 12-13, 2000.New Delhi, India.Abstract: Antiinflammatory and antioxidant effects of Nigella Sativa oil in sensitized animals.



  1. The Annual Scientific Conference of the Egyptian Society of Toxicology 1-3 April, 1998.



  1. Abstract accepted in 25thConference of Pharmaceutical Sciences, December 24-26, 1996.Abstract: Effect of Nigella Sativa oil on the responsiveness of normal and ovalbumin-sensitized guinea pig tracheal muscle.

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