RESIDENT VERSION COMPLICATIONS OF DIALYSIS IN PATIENTS WITH KIDNEY

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Attending Version: Complications of Dialysis in Patients with Kidney Failure

Resident Version

Complications of Dialysis in Patients with Kidney Failure

Created by Dr. Patrick Moran

Objectives:

List the action plan for the 5 stages of chronic kidney disease.
List 5 indications for dialysis in patients with chronic kidney disease.
Name and discuss 5 complications associated with dialysis in kidney failure.
List 2 labs and 1 study in the work-up and management of altered mental status in a dialysis patient.

References:

Levey, A.S., et. al. The National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. Ann Intern Med. 2003;139:137-147.
Brouns R, De Deyn PP. Neurological complications in renal failure: a review. Clin Neurol Neurosurg. Dec 2004;107(1):1-16.
Pastan S, Bailey J: Dialysis therapy. N Engl J Med 1998 May 14; 338(20): 1428-37.
Yu HT: Progression of chronic renal failure. Arch Intern Med 2003 Jun 23; 163(12): 1417-29.
Foley RN, et. al. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 1998;32(5 suppl 3):s112-9.
United States Renal Data System: III. Treatment modalities for ESRD patients. Am J Kidney Dis 1999 Aug; 34(2 Suppl 1): S51-62.
Bailie, G. et. al. Chronic Kidney Disease 2006: A Guide to Select NKF-KDOQI Guidelines and Recommendations. Edited by Nephrology Pharmacy Associates, Inc 2006.

CASE

HPI: A 58 yo male with a history of DM-II, HTN and ESRD is admitted from the ED for AMS. The patient has been on hemodialysis q Monday/Wednesday/Saturday for the past 5 months. He had a portacath placed 3 months ago. The patient’s family reports that everything appeared normal when he returned from dialysis earlier in the day. Then, this afternoon, the patient began to behave erratically – talking to himself and not focusing on conversations or tasks. Other than his AMS today, the patient has tolerated dialysis well and leads an active lifestyle. At the bedside, the patient does not currently have any complaints, but is notably distracted and incoherent.

PMHx:

Kidney failure from diabetic nephropathy
DM-II, now improved control with insulin (last A1c = 9.2 two months ago)
HTN
Dyslipidemia
OSA, uses CPAP intermittently at night

Family Hx: Mother - DM-II, HTN; Father - HTN, AMI @ 52 yo; Sister - DM-II, HTN

Social Hx: Lives with wife and son. Denies using ETOH, tobacco or illicit drugs.

Medications:

1. Lantus

2. ACEi

3. Metoprolol

4. Atorvastatin

5. Calcium carbonate supplements

Allergies: NKDA/NKA

PE: VS: T 99.1, HR 96, BP 96/70, RR 20, O2 sat 93%

Gen: Mildly agitated

HEENT: NCAT, MMM

Pulm: CTA bilat

CV: RRR, 2/6 SEM @ LLSB, no abd/carotid bruits, carotid pulse 2/4 bilat, dorsalis pedis 1/4 bilat

Abd: Obese, +BS, soft, nondistened, nontender in 4 quadrants, no peritoneal signs

Ext: 1+ pretibial pitting edema bilat, no cyanosis

Derm: No rashes, no erythema, warmth, or tenderness at portacath-site (left chest )

Neuro: CN II-XII intact bilat, pt not able to follow commands

1. What factors could contribute to patients’ altered mental status?

2. What is the differential diagnosis at this point?

3. What is your next step in management?

Discussion Outline:

1. Classification of Chronic Kidney Disease (CKD):

Defined as either GFR <60 mL/min/1.73² for 3 or more consecutive months or kidney damage. Kidney damage is defined as the presence of pathologic abnormalities or markers of damage, including blood/urine tests, or imaging studies.

Table 1: National Kidney Foundation: Stages of Chronic Kidney Disease and Action Plan*.

Stage	Description	GFR (mL/min/1.73²)	Action
--	At increased risk	≥60 (with risk factors)	Screening; chronic kidney disease reduction
1	Kidney damage with normal or increased GFR	≥90	Diagnosis and treatment of comorbid conditions, CVD risk reduction
2	Kidney damage with mild decreased GFR	60-90	Estimating rate of progression
3	Moderately decreased GFR	30-59	Eval and treatment of complications
4	Severely decreased GFR	15-29	Preparation for kidney replacement therapy
5	Kidney failure	<15 (or dialysis)	Kidney replacement/dialysis

*The level of kidney function (GFR), regardless of diagnosis, determinesthe stage of chronic kidney disease according to the Kidney Disease Outcomes Quality Initiative (KDOQI) chronic kidney disease classification (level A recommendation).

2. Indications for dialysis:

According to the Kidney Disease Outcomes Quality Initiative (KDOQI), dialysis should be started when:

GFR <10 mL/min/1.73² (Diabetics GFR <15),
Serum Cr ≥8 mg/dL (Diabetics Cr ≥6)**,
Uremic symptoms appear (ie; pericarditis, encephalopathy, coagulopathy),
Fluid overloads are unresponsive to diuresis,
Refractory hyperkalemia,
Severe metabolic acidosis (pH <7.20)

(**Serum Cr alone should not be used to assess kidney function – level A recommendation)

3. Complications associated with dialysis and kidney failure:

Hyperkalemia:

K+ balance normally remains intact in chronic renal failure until the patient’s GFR is <10-20 mL/min/1.73². It is the most common electrolyte abnormality and can cause life-threatening arrhythmias. Treatment options include calcium carbonate/chloride, binding resins, insulin/glucose, bicarbonate, or Albuterol nebs as needed.

Hyponatremia:

In dialysis patients, hyponatremia is usually a dilutional effect, after increased fluid intake while on sodium restriction. It can cause AMS and seizures. Use diuretics only if patient still has some ability to produce urine. If not, then treat with dialysis.

Hyperphosphatemia/Hypocalcemia:

Disordered metabolism of phosphorus, calcium, and bone is referred to as renal osteodystrophy (ie; osteitis fibrosa cystic/osteomalacia). It usually begins when GFR <20 mL/min/1.73². It can cause bony pain, fractures, and muscle weakness. Treat with phosphorus-binding agents.

Acid/base disorders:

Damaged kidneys are not able to excrete the H+ ions that are regularly generated by metabolism (ie; metabolism of proteins). The normal buffering systems of the kidney (ie; NH₃, HCO₃-) are also reduced. The resultant metabolic acidosis has to be buffered by the calcium carbonate and calcium phosphate that is stored in the bone, which, in turn, exacerbates renal osteodystrophy. This state is often worsened by co-morbidities that produce acidosis (ie; COPD, OSA, infection, etc). It can present as hyperpnea. Treat with sodium bicarbonate or, if pH <7.20, with dialysis.

Anemia:

Characteristically normochromic/normocytic because it is primarily caused by a decreased production of erythropoietin by damaged kidneys. Also, patients can have iron deficient anemia. It present as generalized fatigue, however, it also increases the risk of CHF and AMI in these patients.

Infection of vascular access: Usually present with local signs/symptoms such as pain, redness, warmth, or fluctuance around access site. However, fever and sepsis may be present without local signs. Take blood cultures and treat empirically if signs of sepsis.

Cardiovascular:

Hypertension/hypotension: Results from alternating periods of sodium and water retention (ie; between dialysis sessions), and periods of considerable diuresis (ie; during and post-dialysis). These varying states of intravascular volume place patients at increased risk for CHF, syncope, and AMS.
Pericarditis/pericardial effusion: Results from uremia. Can present as pleuritic chest pain, weakness, syncope, or dyspnea. It can lead to cardiac tamponade. Must be treated with dialysis.
Myocardial injury/infarction: More common in patients with ESRD. Can present with chest pain or atypically, such as in diabetics, with hypotension and AMS. Treated as non-dialysis patients with attention to drug selection and dosing.

Neurologic complications:

Uremic encephalopathy typically occurs when the GFR is <15 mL/min/1.73². Tertiary hyperparathyroidism and hypercalcemia are also thought to contribute to the degree of encephalopathy. It presents as lethargy, AMS, or coma and it must be treated with dialysis.

Hyperinsulinemia:

Patients with kidney failure have decreased renal insulin clearance. Because of this, they often require decreased doses of hypoglycemic medications. If insulin therapy is not monitored closely and adjusted, these patients can experience symptoms of hypoglycemia (ie; AMS, palpitations/tachycardia – careful with Beta-Blockers masking cardiovascular symptoms).

Dialysis dysequilibrium syndrome (DDS):

It is characterized by weakness, dizziness, headache, and, in severe cases, AMS. DDS is thought to be caused by repeated fluid shifts and is a diagnosis of exclusion.

4. Workup and Management of AMS in dialysis patients:

ABCs.
Establish new vascular access.
Basic labs: CBC with diff, Chem 10, Cardiac enzymes, Coags, Blood cultures, CBG, UA/UCx (use a foley catheter to check for residual urine or for pyuria).
Other labs to consider depending on patient presentation or 1^st lab results: ABG, lactic acid, albumin, LFTs, UDM.
12-lead ECG and cardiac monitoring (AMI, Arrhythmias, pericarditis).
CXR (CHF, pericarditis, infection).
Fluids: Usually not used unless patient in frank shock. Must thoroughly evaluate cardiovascular and pulmonary status. Fluids may be administered in small 250cc boluses. No LR due to K+ content.
Consult a nephrologist if the patient has: a need for urgent dialysis (see KDOQI recommendations in section II); a significant drop in baseline renal function; signs of infection, obstruction, or aneurysm/pseudo-aneurysm of vascular access.
Consider other causes of AMS if patient has specific risks (ie; a fall, history of TIA, etc), or if initial workup for dialysis-related causes is negative. May require CT of the brain or MRI.

Review Questions:

1) Which one of the following statements about hypo- or hypernatremia is true?

A. A patient with frank symptoms of hypo- or hypernatremia should have his/her serum sodium concentrations corrected over a few hours back to normal levels.

B. The brain fully compensates for hyponatremia within 2-4 hours by making "idiogenic osmoles".

C. The symptoms of hyper- and hyponatremia are mainly due to central nervous system dysfunction.

D. Hyponatremia due to SIADH is most often due to underlying kidney disease.

E. "Pseudohyponatremia" is as dangerous as true hyponatremia.

2) 44 yo male with PMHx of ESRD, DM II, and Gout presents with a two day history of progressive weakness in all 4 extremities. He reports “missing” his last dialysis appointment 3 days ago. Physical exam is all within normal limits except for three findings; Muscle strength 0/5 in lower extremities (LEs), 1/5 in upper extremities, and DTRs in LEs 0/4. Notable labs: NA⁺ 132, K⁺ 6.8. ECG: PR interval=0.25, QRS=0.12, with T-waves that are mildly peaked.

What is the next step in the management of this patient?

A. Kayexalate 25 g PO mixed with 100 mL of 20% sorbitol

B. Calcium chloride 5 mL of 10% sol IV over 2 min

C. Regular insulin 10 U regular insulin and 2 amps D50W IV bolus

D. Lasix 40mg IV-push

E. Urgent dialysis

3) Which of the following is NOT an indication for urgent dialysis for a patient with renal failure?

A. Asterixis and drowsiness
B. Pulmonary edema resistant to diuretics
C. Pericarditis
D. Serum creatinine of 12 mg/dL
E. Serum potassium of 7.8 mEq/L

Post Module Evaluation

Please place completed evaluation in an interdepartmental mail envelope and address to Dr. Wendy Gerstein, Department of Medicine, VAMC (111).

1) Topic of module:__________________________

2) On a scale of 1-5, how effective was this module for learning this topic? _________

(1= not effective at all, 5 = extremely effective)

3) Were there any obvious errors, confusing data, or omissions? Please list/comment below:

_____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

4) Was the attending involved in the teaching of this module? Yes/no (please circle).

5) Please provide any further comments/feedback about this module, or the inpatient curriculum in general:

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