ATP PRODUCTION FOR THE COMPLETE OXIDATION OF GLUCOSE YIELD

Reaction

Comments

Yield of ATP

Glycolysis

Glucose glucose-6-phosphate [activation of glucose]

Consumes 1 ATP

-1

Glucose-6-phosphate fructose 1,6-biphosphate

Consumes 1 ATP

-1

2(glyceraldehyde 3-phosphate1,3-bisposphoglycerate)

[Oxidation of glyceraldyhyde 3-phosphate]

Each produces 1 cytoplasmic NADH

—

2(1,3-bisposphoglycerate3-phosphoglycerate)

Each produces 1 ATP

+2

2(phosphoenolpyruvatepyruvate)

Each produces 1 ATP

+2

C₆H₁₂O₆  2 pyruvate +2H₂O

Oxidation of pyruvate

2(pyruvateacetyl COA + CO₂) [ATP from acetyl CoA]

Each produces 1 NADH

Citric acid cycle

2(isocitrate-ketoglutarate + CO₂)

Each produces 1 NADH

2(-ketoglutaratesuccinyl CoA + CO₂)

Each produces 1 NADH

2(succinyl CoAsuccinate) [direct substrate phosporylation]

Each produces 1 GTP

2(succinatefumarate) [oxidation of succinate]

Each produces 1 FADH₂

+2

2(malateoxaloacetate) [oxidation of malate]

Each produces 1 NADH

Summary: 2 Acetyl CoA  4 CO₂ + 2 H₂O

Electron transport chain and oxidative phosphorylation

2 cytoplasmic NADH formed in glycolysis

Each yields 1.5 ATP

+3

2 NADH formed in the oxidation of pyruvate

Each yields 2.5 ATP

+5

2 FADH₂ formed in the citric acid cycle

Each yields 1.5 ATP

+3

6 NADH formed in the citric acid cycle

Each yields 2.5 ATP

+15

C₆H₁₂O₆ + 6 CO₂ + 36 ADP + 36 P_i 6 CO₂ + 6 H₂O + 36 ATP

Net yield ATP

+30