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Organism


Supplementary Table 3: Overlap between PITA predictions and other microRNA target prediction methods, and among other methods. (a) Comparison between PITA predictions and other methods. For each comparison, shown is the number of targets predicted by the compared method, and the number of these targets that are also predicted by PITA (overlap column). For the PITA predictions, we selected its k highest ranking targets, where k in each comparison is equal to the number of targets predicted by the compared method. (b) Comparison between existing microRNA target prediction methods. For each pair of compared methods, shown is the number of targets of each method, and the overlap. The overlap is computed by constructing a binary set of microRNA-target pairs for each of the methods and counting the number of pairs that appear in both sets. The overlap percentage is given in respect to each of the compared prediction set sizes.


For each comparison, the input set of predictions was narrowed down to include only genes on which both methods have reported at least one target and only microRNAs for which both methods have reported at least one target.


(a)


Organism

Method

Num. Targets

Overlap

Overlap (%)


Human

PicTar

15,345

4,166

27

TargetScan

7,847

1,471

18

miRanda

1,142

183

16

Mouse

PicTar

46,928

9,938

21

TargetScan

19,187

3,214

16


Fly

Stark

8,942

2,314

25

PicTar (s1)

9,535

2,042

21

PicTar (s3)

5,031

939

18

miRanda

9,393

1,887

20






(b)


Organism

Method I

N. Targets I

Method II

N. Targets II

Overlap

Overlap (%)


Human

PicTar

17,137

TargetScan

16,891

13,010

75 / 77

PicTar

16,522

miRanda

3,110

2,148

13 / 69

TargetScan

7,297

miRanda

1,484

880

12 / 59

Mouse

PicTar

51,895

TargetScan

31,683

7,594

14 / 23



Fly

Stark

8,359

PicTar (s1)

6,736

6,487

77 / 96

Stark

6,158

PicTar (s3)

3,891

3,773

61/ 96

Stark

7,644

miRanda

6,162

3,164

41 / 51

PicTar (s1)

7,817

miRanda

7,941

3,455

44 / 43

PicTar (s3)

4,306

miRanda

5,791

2,178

50 / 37



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