MASSACHUSETTS GENERAL HOSPITAL THE MGH TRANSLATIONAL AND CLINICAL RESEARCH

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GENERAL HOSPITAL

MASSACHUSETTS GENERAL HOSPITAL THE MGH TRANSLATIONAL AND CLINICAL RESEARCH

The MGH Translational and Clinical Research Centers

David M. Nathan, MD., Medical Director, CRC
Mason Freeman, MD, Medical Director, TRC

Madhusmita Misra, MD, MPH, Associate Medical Director/Pediatrics

Lynelle Cortellini, MSc, CRA., Administrative Director

Kathryn E. Hall, MS, ANP-BC, NE-BC, Nursing Director

Jane L. Hubbard MS, RD, LDN, CBDT., Metabolism & Nutrition Director

Ashley Elliman, MS, FNP-C, Nurse Practice Specialist

Falisha Porto, MS, AGPCNP-BC, Nurse Practice Specialist

September 24, 2019

To: TCRC Investigators

From: David Nathan and Amanda Griffin

Re: Assays and sample storage

The TCRC laboratory receives tens of thousands of biological samples each year that it processes for assays performed at the designated Harvard Catalyst laboratory (Quest), the MGH core laboratories, or others. In addition to not having the capacity to store these samples, we remain constantly vigilant about samples getting potentially lost owing to the large number of studies performed at the TCRC. Fortunately, we have only misplaced a tiny number of samples of the more than 50,000 samples processed each year. Nevertheless, each sample lost is a real loss to our investigators.

In order to obviate sample loss in our busy laboratory, our prior policy has been to limit any sample storage to 72 hours at most. Such samples can be stored at 4^o, -30^o or -80^o C.

With this e-mail we want to reiterate the policy that no samples processed on the TCRC should remain on the TCRC for more than 72 hours. We will never discard samples left for longer than 72 hours, but study teams should make every effort to pick up their samples as soon as possible after collection. We cannot be responsible for samples that are left for more than 72 hours unless prior approval for longer-term storage has been obtained.

On a related topic, we have recently been asked about the stability of samples in storage for a variety of analytes. Many of our investigators obtain samples over the duration of a study, perhaps over several years, and then perform the assays in large batches at the conclusion of the study. Such batched analyses can mitigate the effects of assay drift, but samples are subjected to variable storage times (usually at -80^o C). Whether such samples are stable in storage for a specific assay must be considered by the investigators at the time of study design and determining this remains the responsibility of the investigator. Our laboratory staff can share assay stability information provided by our central Quest laboratory with investigators; however, it is the research team’s responsibility to determine the stability of samples in storage for the specific assays that will be utilized.

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http://m MASSACHUSETTS GENERAL HOSPITAL THE MGH TRANSLATIONAL AND CLINICAL RESEARCH assgeneral.org./crc

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APPENDIX 2 UNIVERSITY OF MASSACHUSETTS POSITION DESCRIPTION NAME DEPARTMENT
APPENDIX 5 UNIVERSITY OF MASSACHUSETTS REQUEST FOR EQUITY REVIEW

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